10 Best Online Weight Loss Programs With Lab Work Included of October 2026

Ro ranks #1 on this list with a score of 7.6/10 and plans from $299/mo. Scores weigh trust and safety, value, patient experience, product range and reputation.

Of the providers on this list, Sesame Care has the lowest starting price at $59/mo (Weight Loss Program (subscription)). Starting prices often rise with dose or after an intro period, so compare the ongoing price too.

Across the 17 providers we compared, starting prices range from $59 to $448 per month, with a median of $189. 11 of them run an intro offer or first-month discount.

By our category score: trust and safety (30%), value (25%), patient experience (20%), product range in this category (15%) and reputation (10%), with a small bonus for specialists. The full methodology is published on our methodology page.

Yes. Telehealth providers connect you with licensed clinicians who evaluate your BMI, health history, and goals — usually through an online intake, sometimes with a video visit. If you qualify, the prescription is sent to a partner pharmacy and shipped to you. Most programs require a BMI of 30+, or 27+ with a weight-related condition.

Brand-name GLP-1s like Wegovy and Zepbound are FDA-approved drugs made by Novo Nordisk and Eli Lilly. Compounded versions contain the same active ingredient but are prepared by compounding pharmacies and are not individually FDA-approved. Compounded is usually cheaper, though manufacturer self-pay pricing (roughly $149–349/month for Wegovy and $299–449/month for Zepbound, depending on form and dose) has narrowed the gap considerably. Oversight of compounded medication varies by pharmacy — which is why we score sourcing transparency in our trust dimension.

Usually not through cash-pay telehealth platforms — most operate outside insurance entirely. If you have coverage for weight loss medication, it's often cheaper to get a prescription through your own doctor and use insurance at a retail pharmacy. Cash-pay telehealth makes the most sense when insurance won't cover the medication.

In clinical trials, patients on semaglutide lost an average of 15–17% of body weight over about 16 months, and tirzepatide patients lost up to 22.5%. Individual results vary widely, and most patients regain a substantial portion after stopping, so a plan for maintenance matters as much as the medication.